Tejashree Deokule*, Chaitrali Gosavi and Aditya Sarode
The evaluation of thiazole's biological activity, such as antibacterial, antiprotozoal, antitubercular, antifungal and anthelmintic, with an emphasis on their potential medicinal applications, is desirable because the thiazole has an important component effect on the pharmacophores of a large number of medicinally significant molecules. We are particularly interested in investigating newly synthesized aminothiazoles, particularly 2-aminothiazole derivatives, a class of heterocyclic ring systems with antiviral, antimicrobial, anticancer and anti-inflammatory properties, respectively. Numerous human cancer cell lines, including breast, leukemia, lung, colon, CNS, melanoma, ovarian, renal and prostate cell lines, were the subjects of previous in vitro anticancer evaluation studies of a variety of 2-aminothiazole analogs. In its use as a core structure in a variety of therapeutic applications, substitutions at the 2-position of benzothiazole have emerged. Interesting results from studies on the structure-activity relationship show that changing the structure of a substituent group at its C-2 position frequently alters its bioactivity. Although 2-substituted benzothiazoles have numerous therapeutic applications, their anti-inflammatory activity has not been extensively studied. Additionally, the numerous pharmaceutical applications of thiazole derivatives have sparked a lot of interest. A wide range of biological properties can be found in thiazole derivatives, including cardiotonic, fungicidal, sedative, anesthetic, bactericidal and anti-inflammatory properties. Thiazole derivatives are also said to have a wide range of biological activities.
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