Chemical Sciences Journal

4 - Methyl - 2H - Benzo[h]Chromen - 2 - one as Focal Intermediates for the Synthesis of 4 - Methyl - Naphtho [1,2 - b] Pyridin - 2 - one - 1 - (2',3�¢���� - Diphenyl Isoquinolinyl [1,5 - c] Azoles

Abstract

VK Pandey, Z Tusi, S Tusi, MN Joshi

A series of 4-methyl-naphtho [1,2-b] pyridin-2-one-1-(2\\\',3’-diphenyl isoquinolinyl) [1,5-c] azoles were synthesized using 4-methyl-naphtho [1,2-b] pyran-2-one/4-methyl 2H-benzo[h]chromen-2-one 1 as key intermediate. 4-Methyl-naphtho [1,2-b] pyran-2-one 1 were rehabilitated to 4-methyl-naphtho [1,2-b] pyridine-2-one-1-phenyl-4\\\'-carboxylate 2. Compound 2 was further cyclized to 4-methyl-naphtho [1,2-b] pyridine-2-one-1-(3\\\',4-diphenyl-isocoumarin) 3 using benzoin. Finally, four compounds 4, 5, 6 and 7 were obtained using different diamines. The target compounds were evaluated for their antiviral activity against two animal viruses viz. Japanese encephalitis virus (JEV) (strain P20778) and Herpes simplex virus-1 (HSV-1) (strain 753166) on vero cells in vitro.