The global prevalence of overweight and obesity has reached alarming levels, contributing to the burden of chronic diseases. Lifestyle modifications, including dietary interventions, play a crucial role in weight management. In recent years, research has focused on the potential benefits of mineral supplementation to enhance weight loss outcomes. This article will delve into a randomized, double-blind and placebo-controlled trial that investigated the effects of zinc and selenium co-supplementation on resting metabolic rate, thyroid function, physical fitness and functional capacity in overweight and obese individuals following a hypocaloric diet. The intervention group receiving zinc and selenium co-supplementation and the control group receiving a placebo. Both groups followed a hypocaloric diet, which created a calorie deficit to promote weight loss. The intervention group received a daily supplement containing zinc (30 mg) and selenium (200 mcg), while the control group received a placebo. The trial lasted for a specified duration and various measurements were taken at the beginning and end of the study.
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