Journal of Microbial Pathogenesis

A Randomized Clinical Trial of a Toothpaste Including Melatonin and Curcumin to Combat Periodontal Bacteria

Abstract

Celeste Ambrose

Periodontal disease, a prevalent oral health problem, poses serious risks to both oral and systemic health. It involves the chronic inflammation and infection of the structures surrounding and supporting the teeth, primarily due to the accumulation of pathogenic bacteria in the oral cavity. These bacteria, along with the body’s immune response, lead to the degradation of the supporting tissue and bone, which can ultimately result in tooth loss if left untreated. Traditional methods for managing periodontal disease often involve mechanical debridement and the use of antimicrobial agents. However, due to concerns over antibiotic resistance and the adverse effects associated with some chemical agents, there is a growing demand for alternative treatments that are both effective and safe for long-term use [1].