NAFLD (non-alcoholic fatty liver disease) is a type of chronic liver disease that is linked to insulin resistance and the metabolic syndrome. The condition can advance from simple steatosis to steatohepatitis and eventually cirrhosis. Over the last few years, compelling data has established a strong relationship between NAFLD and cardiovascular disease, ranging from coronary artery disease to subclinical carotid atherosclerosis. Cardiovascular mortality is the leading cause of death among NAFLD patients, according to long-term follow-up studies. Furthermore, NAFLD has been linked to endothelial dysfunction, increased pulse wave velocity, increased coronary artery calcifications, and increased carotid intima media thickness, all of which are known CVD markers. NAFLD has been linked to a number of CVD risk factors, including insulin resistance, abdominal obesity, dyslipidemia, hyperuricemia, chronic renal disease, and type2 diabetes, and is considered a part of the metabolic syndrome.
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