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Journal of Metabolic Syndrome

ISSN: 2167-0943

Open Access

A Study of Glycemic, Insulinemic and Lipidemic Abnormalities in Controlled vs. Uncontrolled T2dm with Particular Reference to Hba1c% Level

Abstract

Amrita Bhowmik1,2, Mossihuzzaman Mohammed3, Begum Rokeya4* and Yearul Kabir

 The global incidence of diabetes is escalating at an alarming rate. This study aims to compare glycemic control, insulin resistance, lipid profiles, and serum creatinine levels in individuals with controlled and uncontrolled diabetes and assess clinical parameters based on the duration of uncontrolled diabetes. Methods: A cross-sectional study was conducted on 357 individuals with T2DM aged 40–60 years. Participants were divided into two groups based on HbA1c% levels: controlled diabetes (HbA1c ≤ 7.0%, n=143) and uncontrolled diabetes (HbA1c>7.0%, n=214). Further subdivision categorized subjects by disease duration: short-term (5 years). Fasting Blood Glucose (FBG), insulin, HbA1c%, triglycerides, total cholesterol, HDL-C, LDL-C, and creatinine levels were measured using standardized techniques. Indices such as HOMA B%, HOMA S%, HOMA IR, QUICKI, and Sr HOMA were calculated using appropriate methods. Statistical analyses were performed using independent t-tests and Fisher's exact test, with significance set at p < 0.05.

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Citations: 48

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