Chemical Sciences Journal

Advance Development of Guanosine Containing Nucleopeptides

Abstract

Dorsainvil Brown*

In this article, we describe the creation and characterisation of self-assembling nucleopeptides containing guanosine that can form nanosheets and nanofibers. We suggest that the nucleopeptide's peptide component drives the assembly into -sheet structures, with hydrogen-bonded guanosine generating additional secondary structures cooperatively inside the peptide framework. This is based on spectroscopic and microscopy studies. It's interesting to note that the C-terminal peptide chemistry, rather than the metal cation responsiveness common to guanine-based materials, is what drives the different supramolecular morphologies. This research will aid in the advancement of the design of applications for these supramolecular guanosine-containing nucleopeptides and demonstrates the structural diversity of self-assembling nucleopeptides.