Over the last few decades, nose-to-brain medication administration has piqued attention as a potential treatment for a variety of CNS illnesses and psychiatric disorders. Several nasal formulations have been created to bypass the blood-brain barrier and deliver medications directly to the CNS via the olfactory and trigeminal pathways. However, medication absorption by the nasal mucosa is poor, and the volume of the nasal cavity is small, making nose-to-brain drug transport difficult.
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