Molecular Biomarkers & Diagnosis

Advanced Colorectal Neoplasm Screening in First-Degree Relatives is Better Understanding as Cruciform Screening

Abstract

Shao-Ping Yu*, Guang-Yao Wu, Zong-Quan Wen, Xiao-Hong Cen, Xiao-Dong Lin, Song-Hu Li, Xian-Guang Huang, Fu Zhang, and Mei-Ting Huang

Aim: Colonoscopy screening of colorectal neoplasm in first-degree relatives is reported frequently, and is recommended in guidelines. However, data from China is limited. This observation study is to evaluate the current situation in Dongguan, China.

Methods: All first-degree relatives were recommended to perform colonoscopy screening when a proband is found in a family. They were divided into 3 groups, the down, up and crossing screening group (children, parents and siblings of proband). Control group rolled in healthy people who underwent colonoscopy while medical examination in our hospital. All subjects ranged from 30-80 (not included) years old. Advanced colorectal neoplasm is defined as: high-grade adenoma, villioustublar adenoma, adenoma with diameter ≧ 1 cm and colorectal cancer. Colonoscopy findings of lesions, site and size of the ACNs and polyp, pathology results of all subjects were recorded. Statistical analysis was run with SPSS 19.0.

Results: In 52 subjects of the Down screening group, 6 were found to be CANs, 9 were adenoma, the overall morbidity in the group is 28.8%. 8 out of 43 subjects in up screening group were found CANs, 7 were adenoma, making the overall morbidity is 34.9% of the group. There were 3 subjects in crossing screening group out of 28 found to be CANs, 5 subjects were adenoma, overall morbidity of the group is 28.6%. Comparing to the control group, there were 176 subjects involved, 15 of them were found to be CANs, 9 were found adenoma, overall morbidity is 13.6% in control group. Statistical analysis indicates that there were significant statistical differences when comparing the down, up and crossing screening group to control group (all p<0.05).

Conclusion: First-degree relatives of proband in Dongguan have a high incidence of colorectal neoplasm, it is recommended to run colonoscopy screening. And it is better understanding as ‘Cruciform screening’ while screening of first-degree relatives.

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