Organ transplantation has undergone significant advancements and witnessed breakthroughs in recent years, leading to improved patient outcomes and expanding the possibilities for successful transplantation. This mini-review provides an overview of the key innovations in organ transplantation. It explores advancements in organ preservation techniques, such as machine perfusion systems that mimic the human body's conditions, enhancing organ viability. Immune system modulation has also seen progress with the development of more targeted and effective immunosuppressive drugs and personalized cellular therapies. The field of organ bioengineering and regenerative medicine offers hope for overcoming the organ shortage by creating functional organs using bioengineering techniques and stem cell technologies. Xenotransplantation, the transplantation of organs between species, has become more viable due to genetic engineering and immunomodulation advancements. Additionally, artificial organs and assist devices have improved the quality of life for patients awaiting transplantation or ineligible for organ transplantation.
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