Journal of Microbial Pathogenesis

Agents that Attack the Bacterial Cell Wall as Weapons against Gram-positive Infections

Abstract

Mira Tamsin

The bacterial cell wall is an essential structural component that ensures the survival of bacteria under various environmental conditions. For Grampositive bacteria, the cell wall not only provides structural integrity but also plays a pivotal role in interactions with the host and the bacterial pathogen’s virulence. Gram-positive bacteria, characterized by a thick peptidoglycan layer, are involved in various infections, from minor skin infections to lifethreatening diseases such as pneumonia, sepsis, and meningitis. Due to the clinical significance of these infections and the growing problem of antibiotic resistance, agents that target the bacterial cell wall have become a crucial part of the antimicrobial arsenal.