Genome-wide analysis in human embryonic stem cells (hESCs) reveals that the Hippo signaling pathway provides synthetic viability in the absence of ATM (Ataxia Telangiectasia Mutated) protein, essential for DNA damage response. The Hippo pathway, known for regulating cell proliferation and apoptosis, compensates for ATM deficiency by promoting cell survival and potentially maintaining genomic stability. This discovery highlights a critical compensatory mechanism and suggests therapeutic potential in targeting the Hippo pathway for conditions associated with ATM deficiency, such as Ataxia Telangiectasia and certain cancers, emphasizing the importance of personalized medicine approaches.
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