This study used the elevated plus-maze model (EPM) and light dark model to examine the anxiolytic effects of aqueous extract of Cucurbita maxima seeds (AECM) in mice (LDM). The extract was given orally in two doses of 100 mg/kg (low dose) and 200 mg/kg (high dose) and it was evaluated for the quantity of participants and the length of time spent in the open and closed arms of the EPM. the quantity of entries and the amount of time spent in light and dark. The impact of this was contrasted with that of the common medication diazepam (1.0 mg/kg i.p.). In this study, mice administered with AECM (100 mg/kg and 200 mg/kg) spent more time and made more arm entries in the elevated plus-open maze's arms than control mice did. Mice also spent more time in the lighted side of the light and dark test than control mice did. The results of the current investigation showed that both models of anxiety may be treated with Cucurbita maxima seeds. In our investigation, it was immediately evident that tryptophan is present in Cucurbita maxima seeds and that it reduces anxiety. The results of the current investigation suggest that giving AECM to mice had anxiolytic effects.
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