Medicinal Chemistry

Anti-diabetic Activity of Synthetic Aryltetalin Derivatives

Abstract

M. Chaitramallu*, G. R. Parvathi, Devaraju Kesagodu and Ranjini

The aryltetralin derivatives were extracted from plant and also synthesized using tetralone as a starting material. They were synthesized by replacing 1,3-methylene dioxy ring with dimethoxy, hydroxy, methyl, chlorine, hydrogen and methoxy group. The structure of the final compounds was confirmed by ¹H NMR, ¹³C NMR, mass spectra and elemental analysis data and the analogues were screened for anti-diabetic activity. It is noteworthy all the synthesized derivatives exhibits good anti-diabetic activity with respect to extracted aryltetralin compound.