Ali A Dawood, Mahmood AA Altobje and Eman Y Thanoon
Background: Hepatitis A and C viruses are common causing hepatitis (inflammation of liver). Acute and chronic liver infections are characterized by the expression of pro anti-inflammatory cytokines. Human interleukin 6 (IL-6) alliance is interferon beta 2 (designation used in this study) a multifunctional cytokine that interfere in the regulation, maturation and differentiation of immune response. Objective: The aim of this study is to demonstrate the level of IFN-β2 and correlates with AST level in patient’s serum with hepatitis A and C infections. Methods: We evaluate 46 patients presumably with acute HAV and chronic HCV whom have positive HAV IgM, HCV Ab respectively. AST chemical serum levels were detected using kit of an automated chemical Analyzer. IFN-β2 serum level was demonstrated using ELISA technique. Correlation between parameters was evaluated using SPSS and Tableau statistical software. Results: IFN-β2 serum level is raised with CHC more than AHA compared with control samples. AST level was elevated with CHC infections more than AHA infections. The correlation coefficient between IFN-β2 level and AST is significant value with CHC patients but is not value with AHA patients. There is a significant correlation between IFN-β2 and AST levels. Negative correlation coefficient emerged between age parameter and groups of hepatitis. Conclusion: IFN-β2 levels elevated with the increase of AST levels in patients with chronic hepatitis C. The serum levels of IFN-β2, AST varied in different courses of acute hepatitis A and chronic hepatitis C infection. We speculated that measuring levels of IFN-β2 and AST could be used as an indicator to judge the patient's condition with CHC, but not with AHA patients.
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Journal of Infectious Diseases and Medicine received 59 citations as per Google Scholar report
