Cancer Science & Therapy

Autologous Transplantation of Cryopreserved Ovarian Tissue to the Upper Extremity for the Preservation of Ovarian Function in Young Patient with Cervical Carcinoma

Abstract

Chen Meiyi, Shao Yin, Ma Liguo, Zhuang Yongqing, and Wang Xiaomei

For women of reproductive age with cervical carcinoma, they usually receive not only standard surgical treatment but also postoperative radiotherapy to increase the cure rates. However, infertility and premature ovarian failure are often occurred after radiotherapy. Autotransplantation of cryopreserved ovarian tissue is a new technique for preserving gonadal function for cervical cancer patients of reproductive age. Here, a successful ovarian function recovery through cryopreservation and autotransplantation in a case of 28-year-old patient with cervical cancer was reported. In brief, a slow-programmed freezing/thawing method was conducted for ovarian cortex cryopreservation. Six thawed ovarian cortical slices were transplanted to the left upper arm after the radiotherapy. The ovarian endocrine functions and follicle growth was successfully improved to normal level at 12 months after autotransplantation. In conclusion, autotransplantation of cryopreserved ovarian cortex for ovarian function preservation is a viable option for cervical cancer patients to gain the quality of life and avoid the suffering from conventional menopause hormone therapy.