Journal of Clinical Case Reports

Bilateral Anotia with Exposure to Retinoic Acid during Pregnancy

Abstract

Atis A, Acar D, Talmac M, Polat I, Yilmaz E and Gedikbasi A

Isotretinoin (13-cis retinoic acid) is the most potent known inhibitor of sebum production and is by far one of the most effective antiacne medications for the treatment of severe and scarring acne, but it has been shown to be teratogenic when used during pregnancy. The risk of malformations in the population is 3-5%, but it has been reported to increase to almost 30% in women exposed to isotretinoin.