Journal of Tissue Science and Engineering

Bio-Engineering of Wounds by PRP Led Regeneration

Abstract

Mahakalkar C, Shrivastava S, Gupta A, Naik S, Kaple M and Chandanwale K

Platelet rich plasma (PRP) therapy is one of the biological interventions in regenerative medicine with a sure success in clinical translations of wound healing. Platelet rich plasma is an autologous plasma fraction of peripheral blood and it’s the simplest intervention of regenerative medicine. It is rapidly extending to multiple clinical fields because of its easy use and biosafety which facilitates translation in humans. The biggest advantage over other therapies is it’s being autologous, no adverse events or reactions are encountered. The economic as well as social burden caused due to chronic and degenerative disease is well cared by this autologous therapy. The clinical applications have proven its efficacy and efficiency in healing all types of wounds. The microscopic and histopathological changes in the tissues after PRP therapy are described in this article. The changes in the tissues have evoked the transformation from fibrosis led healing to collagen led healing; a bioengineered mechanism of PRP led regeneration of wounds.