Bone Marrow Edema Syndrome (BMES) is a clinical syndrome of unknown etiology characterized by the acute onset of pain gradually worsening over several weeks to months. Radiographic changes occur, but laboratory studies are generally unremarkable. It can primarily affect the foot and ankle and should be considered in the differential diagnosis of patients with acute foot and ankle pain, particularly in middle age men, and women in the third trimester of pregnancy. I here present 2 case reports of BMES of the ankle. Appropriate conservative treatment resulted in resolution of symptoms. Bone marrow edema syndrome can present a diagnostic challenge, but awareness of the typical presenting features and investigation findings can makes the diagnosis more accessible.
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