Journal of Pediatric Neurology and Medicine

Brca2/Fancd1 is Necessary for the Formation of the Pronephros, According to the Zebrafish Kidney Mutant Zeppelin

Abstract

Regula Bartha*

Because the kidneys filter the blood, reabsorb necessary metabolites and solutes, and collect remaining waste products for eventual excretion, the renal system is essential to homeostasis. During the development of a vertebrate species, up to three kidneys of varying complexity are formed. These kidneys can be functional or merely relics, as these forms gradually deteriorate and vanish when the next organ form appears. The pronephros, mesonephros, and metanephros are the three renal iterations that emerge from the intermediate mesoderm (IM). Nephrons are the individual excretory units that make up each of these kidney types. Nephrons typically have three parts: a glomerular blood filter, a tubule, and a duct. However, there are some exceptions, such as aglomerular fish.