Journal of Surgery

Breast Contralateral Metachronous Cancer: Metastases or Second Primary Beast Tumor?

Abstract

Viorica Vidu, Vlad Herlea, Vasile Popa, Ciprian Aldea, Daniela Cristea, Mihai Cătălin Roşu and Daniel Gavrilă

Breast contralateral metachronous cancer is relatively rare. Familial history, BRCA 1 and BRCA 2 mutations, histopathologic type, stage of primary neoplasia and hormone status, is considered risk factors for breast metachronous cancer. The differential diagnosis between a breast contralateral metachronous cancer and a distant metastasis from the primary tumor is difficult and a subject of debate in the literature. We present herein two cases with breast metachronous contralateral tumors; the first is considered as distant metachronous metastasis and the second case, as a second primary tumor. A literature review was also performed.