Portia Ping Zheng* and Wanchao Wang
Background: Burger’s disease is an autoimmune disease? And what is the immunological pathogenesis? It has not been deeply researched but still attracts the attention of scholars. In our early study we reported that TAO may be an autoimmune disease involving hypersensitivity Type III and Type IV.
Methods: In this study we further explored the immune pathogenesis of TAO based on initial research.
Results: We detected humoral immunity (Ig E) in 28 cases using Enzyme-Linked Immunosorbent Assay (ELISA). Antigen-antibody complex depositing on the vessel wall in 18 cases, and anti-vessel antibodies in 28 cases using three kinds of immune-labeling techniques (immunofluorescence labeling, immunoenzymatic staining and immuno-gold-silver staining). The result shows Ig E levels were significantly high (P<0.01). As high as 86% of anti-vessel antibodies in serum were found (P<0.001), and the auto-antibodies against the vessel were combined directly with vascular collagen. Antigen-antibody complexes deposited on the vascular wall.
Conclusions: These findings further confirm TAO is an autoimmune disease involving multiple hypersensitivity reactions. This is mainly Type III hypersensitivity and type II in addition to type IV. The elevated Ig E suggest that TAO may a type I hypersensitivity involved.
Trial registration: Not applicable.
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