Hereditary retinoblastoma and Li-Fraumeni syndrome, two rare genetic conditions, raise the likelihood of bone cancer in families. The disease that affects Paget's bones Paget's disease of the bone, which mostly affects the elderly, raises the risk of developing bone cancer in later life. The most common type of bone cancer is osteosarcoma. The cancerous cells in this tumor make bone. The bones of the arm or leg are most frequently affected by this kind of bone cancer in children and young adults. Osteosarcomas rarely spread beyond the bones.
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