Journal of Cytology & Histology

Characteristic Cytological Features of Cervical Clear Cell Adenocarcinoma: A Report of 4 Cases

Abstract

Kenzo Sonoda, Miwako Nogami, Masaki Naka, Fumihiko Ookubo, Hiroaki Kobayashi, Hideaki Yahata, Kaoru Okugawa, Eisuke Kaneki, Yoshinao Oda and Kiyoko Kato

We experienced 5 cases of clear cell adenocarcinoma (CCAC) of the cervix in the 10-year period from 2003 to
2012. Because a specimen from one of the cases was poorly preserved, we analyzed cytological features of the
4 remaining cases. Characteristic large, pale-staining atypical cells with prominent, round nuclei were seen in all
cases. Additionally, a hobnail appearance and basement membrane-like substance were detected in 3 cases, and a mirror ball cluster-like morphology was found in 1 case. Cervical CCAC has been reported to be difficult to diagnose by cytology; however, we were able to diagnose these 4 cases by recognizing several characteristic cytological features.