Journal of Bioengineering & Biomedical Science

Chemical Approach to Signal Transduction by Inositol Triphosphate

Abstract

Shoichiro Ozaki*

Berridge discovered that inositol 1,4,5-trisphophate (IP₃) was generated at the cell surface in response to cell stimulation and functioned as a second messenger to release Ca²⁺ from internal stores. Ozaki et al. succeeded in the first total synthesis of optically active IP₃ by 13 steps. He supported the signal transduction studies by supplying necessary reagents such as IP₃, other IP_x, phosphatidyl inositol, new synthetic methods and reagents. He discovered the regulators of Ca²⁺ release and consequent cellular processes.