Journal of Oncology Translational Research

Chromatin attenuation to release marker dots/supernumerary marker chromosomes must be an epigenetic mechanism signalling chromosomal mutagenesis

Abstract

Hit Kishore Goswami

Studies on genotoxic assessments by lymphocyte cultures on 600 persons exposed to MIC gas and various control subjects and family members in Bhopal had also established that chromosomal damages have been installed among seriously exposed persons. This was a remarkable find to record in slides from lymphocyte cultures of exposed persons and confirm the presence of chromatin marker dots which were seen emanating from specific chromosomes (2). Obviosly this becomes imperative to reemphasize that these chromatin dots seen emanating from chromosomes are decidedly early indicators of chromosomal mutagenesis. We have confirmed by G, and C banding as well as by Feulgen’s staining and fluorescence procedures that these are chromatin bodies found in patients of cancers (bone, breast, lung and colon in particular) and sometimes in a few of their family members (3). Family members prone to cancer were found to exhibit marker dots and developed clinical signs of cancer after 03 to 05 years after our report. Marker dots measuring 2-to-3 micron emanate from different chromosome in several metaphases in preparations from cancer patients obviously, it appears that the molecular attenuation of chromatin structures movable from chromosomes is related with triggering neoplastic transformations (4).