Rhabdoid meningiomas have variable histological findings, and a wide range of chromosomal copy number alterations are linked to an unpredictable disease course. We analysed 305 RM samples from patients previously reported in the literature, as well as 33 samples from 23 patients studied in our laboratory, in this study. The most common chromosomal alteration was monosomy 22, which involved the minimal but most common recurrent region loss of the 22q11.23 chromosomal region, followed by losses of chromosomes 14,1,6, and 19, polysomies of chromosomes 17,1q, and 20, and gains of 13q14.2, 10p13, and 21q21.2 chromosomal regions. Based on their CNA profile, RM could be divided into two genetic subgroups with distinct clinicopathologic features defined by the presence of chromosomal losses only or combined losses and chromosomal instability.
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