Luo Q, Peng J and Dai L
Nicolau syndrome (NS) is a rare but well-known complication of intramuscular Benzathine Penicillin (BP) injection, manifesting by symptoms of livedoid discoloration of the skin, edema, as well as classical clinical features of myalgia, muscle weakness and pigmenturia immediately after intramuscular. NS or embolia cutis medicamentosa was first described in 1925 by Nicolau and Freudenthal following intramuscular injection of bismuth salt for the treatment of syphilis. Since then, a few cases have been reported both in adult and children.
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