Journal of Blood & Lymph

Commentary on ?Crosstalk between DNA Damage Repair and Metabolic Regulation in Hematopoietic Stem Cells??

Abstract

Peiwen Fei*, Wei Du, Jun Zhang and Herbert Yu

We recently shared our thoughts on a topic “Crosstalk between DNA Damage Repair (DDR) and metabolic regulation in Hematopoietic Stem Cells (HSC) [1]”. Research has increasingly focused on the crosstalk between cellular processes in recent years even considering mathematical modeling [2,3]. A growing body of literature indicates that the metabolic state of HSCs not only influences their ability to repair DNA but that DDR pathways, in turn, affect cellular metabolism [4-8]. This bidirectional relationship is particularly important for maintaining HSC homeostasis during periods of stress or aging and may have profound implications for both normal hematopoiesis and hematological diseases [9-12].