This comparative analysis explores the distinctive features of Osteochondritis Dissecans (OCD) and Avascular Necrosis (AVN), two orthopedic conditions characterized by compromised blood supply leading to bone pathology. While sharing the commonality of vascular compromise, OCD primarily affects the knee joint, resulting in the detachment of subchondral bone and overlying articular cartilage, often attributed to repetitive micro trauma. In contrast, AVN exhibits a broader spectrum of etiologies and frequently involves weight-bearing joints, with the hip being a common site, leading to ischemia-induced bone cell death. Through a comprehensive examination of pathophysiology, clinical presentation, diagnostic approaches and treatment strategies, this analysis aims to provide clinicians with valuable insights for differentiating between and managing these distinct orthopedic entities.
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