Shambavi J. Rao, Kelsie Pierre and Luis F. Barroso*
When it comes to simple anatomy, the colon, rectum and anus all seem to be part of the same gastrointestinal highway, so wouldn’t the cancers that develop in these different...stretches, be the same? While colon and rectal cancers can be similar and are often referred to collectively as colorectal cancer, anal cancer is completely different in significant ways, including the cell type where cancer begins, the cause of the cancer, who gets this cancer, and how we treat it. Anal cancer is more similar to cervical cancer because the tissue that lines the anus (where anal cancer typically develops) is like the tissue that lines a woman’s cervix. Most anal cancers are related to human papillomavirus (HPV) infection like cervical cancer, and the precancerous and cancerous changes that we see in the anal canal are also similar to cervical cancer. Cervical disease and analcentric malignancy share numerous likenesses including causation by oncogenic human papillomaviruses; in any case, critical contrasts exist in their study of disease transmission, hazard factors, biologic conduct, the executives, and treatment. Albeit uncommon, the rate of anal-centric malignant growth is alarmingly high and keeps on expanding in high-hazard populaces, especially men who have intercourse with men paying little heed to their human immunodeficiency infection (HIV) status. There are no public evaluating rules for butt-centric malignancy. Utilizing the achievement of cervical malignant growth screening as a model, anal-centric disease screening approaches apply anal-centric cytology, high-goal anoscopy, and guided biopsy to direct treatment and the executives’ techniques.
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