Nuclear Medicine & Radiation Therapy

Comparison between Myocardial Perfusion Scintigraphy Using Technetium 99m Tetrofosmin and Conventional Coronary Angiogram in Assessing Coronary Artery Disease at Royal Hospital, Oman

Abstract

Khulood Al-Riyami, Alshaima Al-shammari, Mohammed Al-Zidjali, Mohammed Al-Shidi, Abdullah Al-Riyami and Naima Al Bulushi

Objectives: To determine the sensitivity and specificity of MPS when compared to CCA in detecting coronary artery disease and compare it with published data. To compare myocardial perfusion findings (MPS) with conventional coronary angiography (CCA) results according to their territory.
Methods: The study included men and women >35 years of age who have undergone MPS and CCA within seven months due to suspected CAD with no interval major cardiac event or intervention between 2013 and 2014 at Royal Hospital, Oman.
Results: A total of 95 patients were included in the study. The sensitivity and specificity of MPS for detection of coronary artery stenosis (>=70%) were 95.45% and 47.06% respectively and for detection of coronary artery stenosis (>= 50%) were 82.76% and 43.24% respectively. The sensitivities and specificities of MPS for detection of Left anterior descending (LAD), Right coronary artery (RCA) and left circumflex (LCX) territory stenosis (>=70%) were (59.38% and 68.25%), (73.08% and 63.77%), and (42.31% and 81.16%) respectively. The agreement between MPs and CCA for coronary artery stenosis >=70% according to territory, the kappa value ranged 0.24- 0.30, p<0.0001.
Conclusion: The sensitivity and specificity of MPS at Royal Hospital for detecting critical stenosis was comparable with published data, 95.45% vs. (81%-93%), 47.09% vs. (38%-70%), respectively. There was a fair agreement in results between territory based MPS and CCA for coronary artery disease.