Amod P Kulkarni and Girish J Kotwal*
The global pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is not yet over. The widespread infection from the COVID-19 virus resulted in unusual hyperinflammatory response in certain individuals leading to the cytokine storm and mortality. Efficacy and safety of the current therapeutic strategies in treating these patients still needs to be further probed. Although scientists across the globe are busy delineating the cause of unusual immune response in some of the COVID-19 patients, the underlying aetiological complexities associated with the cytokine storm still needs to be unearthed. To this goal, a very high level of pro-inflammatory markers followed by a sustained unexpected and prolonged antibody response in a well-documented case of surviving severe COVID-19 infection with simultaneous cytokine storm during the COVID-19 pandemic before vaccines against COVID were widely available, is the focus of this scientific report. On one hand significant number of deaths following severe COVID infection can be attributed to cytokine storm, it may also have been a reason why antibody levels from severe COVID infection may provide longer term protection in survivors.
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