Molecular Biology: Open Access

Deciphering the Central Dogma of Telomere: New beginnings

Abstract

Divyalakshmi Saini and Vinay Jain*

Telomeres have always been an enigmatic structure since their discovery. The unravelling of new findings and changing concept of central dogma at telomeres have intrigued the telomere biologists further. Telomeres have been considered antennas for various environmental stress and detectors of cellular DNA damage. The translation of mammalian telomeres has further raised many questions about its involvement in maintaining the genomic integrity and have opened doors for new era of research in telomere biology and telomere-related diseases. Unravelling the mysteries of telomeric organization and its regulation will have widespread impact in various fields including cancer treatment, space exploration and aging disorders.