Molecular Biology: Open Access

Deregulation of Extracellular Matrix Components in Hypertrophic and Dilated Cardiomyopathy

Abstract

Beutline Malgija M*, ES Deepak Shyl and Shanmughavel P

Cardiomyopathies are an important category of cardiovascular diseases associated with cardiac dysfunction. The extracellular matrix (ECM) plays a vital role in maintaining cardiac homeostasis by offering structural support, assisting mechanical transmission and by providing vital signals to different cells of the cardiac system. Alterations in the ECM profile are associated with the pathogenesis of heart failure. This review discusses on the alterations in gene expression signatures of cardiomyopathy with special emphasis of hypertrophic and dilated cardiomyopathy. Understanding the mechanism of ECM remodeling and regulation in cardiomyopathy is helpful in the identification of therapeutic targets to diminish remodeling, reduce cardiac dysfunction and stimulate myocardial regeneration.