Medicinal Chemistry

Design and Synthesis of New Compounds of Phthalazindion and its Anticonvulsant Activity

Abstract

Rezk R. Ayyad, Ahmed M. Mansour and Ehab M. Mostafa

In this work we synthesized 6,7-Dichloro-1,4-(2H,3H) phthalazinedione (I) [1] and its salt (II) which react with different alkylchloroacetates, afforded
compounds III1-6. When reacted, the compound III2 with ammonia and different amines we obtained on IV and V1-7 respectively. The compound
III2 also react with Hydrazine hydrated, result the compound VI, afforded compound (hydrazide) Hydrazied condensed with different aldehydes,
we obtained on compounds VIII1-10. The compounds III1, III2, III3, III4, III5, IV, V1,V2, V3, VI, VII1, VII5, VII6,VII9, VIII1, VIII2, VIII7 and VIII8 tested as
anticonvulsant against phenobarbitone as reference drug. The compounds III1-3, IV, V3, VI, VIII1,2 showed the most activity while the compounds V2,
VII6,9 revealed moderate Introduction, finally compound VII5 was the lowest activity.