Medicinal Chemistry

Design and Synthesis of Some New Derivatives of 6,7-Dicholorophthalazine 1,4-(2H, 3H) dione for Pharmacological Testing as Anti-convulsant Agents

Abstract

Ehab M. Mostafa, Rezk R. Ayyad, Ahmed M. Mansour, Yomna A. Salem, Kazem Mahmoud and Yasser Abdel-Aleim

In the present work we synthesized some new compounds of Design and Synthesis of Some New Derivatives of 6,7-Dicholorophthalazine 1,4-(2H, 3H) dione via the reaction of
4,5-Dicholoro phthalicanhydride with hydrazine hydrate resulted 6,7-dicholorophthalazine 1,4-(2H, 3H) dione (I). The compound (I) reacted with alcoholic potassium hydroxide to obtain the potassium salt of 6,7- Dicholorophthalazine 1,4-(2H, 3H) dione (II). Also the acetanilide derivatives (III) condensed with compound (II) in dimethylformamide (DMF) on water bath for six hours, gave compounds (IV 1-12) which choose some of them to test as anti-convulsant activity compared with phenobarbitone sodium as standard reference drug. The choice new compounds which tested revealed anti-convulsant activity.