Medicinal Chemistry

Design, Synthesis and Biological Evaluation of Novel Class Diindolyl Methanes (DIMs) Derived from Naturally Occurring Phenolic Monoterpenoids

Abstract

Jamatsing D Rajput, Suresh D Bagul, Samina K Tadavi, Pravin S Karandikar and Ratnamala S Bendre

Several Diindolyl alkanes and their derivatives have been isolated from plant and marine sources. Among the various derivatives of indoles, Diindolyl methanes have wide medicinal applications such as to induce apoptosis in human cancer cells, antibacterial, Anti-inflammatory, antiviral and hormonal control activities. Therefore, they play essential role in marine as well as terrestrial living systems. In present studies we report novel class of Diindolyl methanes prepared from natural phenolic monoterpenoids, via ortho formylation of phenolic monoterpenoids (Carvacrol, Thymol and Eugenol), followed by synthesis, characterization, anticancer, antioxidant and α-amylase inhibitory activities. All the synthesized derivatives show moderate anticancer activities against human breast cell line MCF7, good antioxidant and α-amylase inhibitory activities using DPPH and α-amylase assay respectively.