Medicinal Chemistry

Design, Synthesis, Computer Modeling and Analgesic Activity of Some New Disubstituted Quinazolin-4(3H)-ones

Abstract

Rezk A Ayyad, Helmy M Sakr and Kamal M El- Gamal

A series of substituted quinazolin-4(3H)-ones (VIII1-12) have been synthesized by treating 3-amino-2- benzylamino-substituted- quinazolin-4(3H)-one VII1-4, with different aldehydes. The starting material 3-amino-2- benzylamino substituted- quinazolin-4(3H)-one VII1-4 was synthesized by nucleophilic substitution of thiomethyl group of 3-amino-2-methylthio-substituted- quinazolin-4(3H)-one VI1-4 with benzylamine. The synthesized compounds VIII1-12 was investigated for analgesic activity. All the test compounds exhibited significant analgesic activity in comparison with paracetamol.