Multi-drug resistant bacteria pose a significant threat to global public health, rendering many conventional antibiotics ineffective and exacerbating the burden of infectious diseases. The development of novel antibiotic agents capable of overcoming resistance mechanisms is crucial for addressing this challenge. This review explores recent advances in the discovery and development of novel antibiotics to combat multi-drug resistant bacteria. From innovative screening approaches and target identification strategies to the optimization of drug candidates and the exploration of alternative antimicrobial modalities, researchers are employing diverse methodologies to identify new therapeutic options. Despite the complexities and challenges associated with antibiotic development, ongoing efforts hold promise for replenishing the antibiotic pipeline and safeguarding against the growing threat of antimicrobial resistance.
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