Nuclear Medicine & Radiation Therapy

Difference between T Classification, Histopathological and Biohumoral Characteristics of the Two Most Common Papillary Carcinoma Subtypes

Abstract

Nenad Laketic, Kata Kovacic and Aleksandar Simic

Papillary thyroid carcinoma is the most common thyroid gland cancer. Among several subtypes, classical (CVPC) and follicular (FVPC) subtype are the most frequent. The most important tumor characteristics for therapy planning and outcome are size/presence of extra thyroid invasion, multicentricity, lymphatic, vascular and capsule invasion, spreading in local lymph nodes. Level of Thyroglobulin is indirect indicator of tissue remnant after surgery. Among 20 patients with CVPC and 33 with FVPC we found out that there is statistically important difference between these two subtypes of PC regarding T stadium, lymphatic and capsule invasion and spread in local lymph nodes of the neck. CVPC has these characteristics significantly more often than FVPC. The difference between these two subtypes is not statistically important regarding multicentricity, vascular invasion and the level of thyroglobulin.