Journal of Bioengineering & Biomedical Science

DNA Biosensors-A Review

Abstract

Kavita V

Recent advances in developing biosensors which are sensitive and specific have opened new opportunities for DNA biosensors. DNA biosensors, based on nucleic acid recognition methods, are being developed towards the assay of rapid, simple and economical testing of genetic and infectious diseases. Moreover, the detection of specific DNA sequence is of significance in numerous areas including clinical, environmental and food analysis. Advancements in technology like SELEX and SAM are being used to develop better detection methods (both Direct and Indirect detection) for DNA Biosensors. Unlike enzyme or antibodies, nucleic acid recognition layers can be readily synthesized and regenerated for multiple uses. DNA biosensors and gene chips are of major interest due to their great potential for obtaining sequence-specific information in a faster, simpler and cheaper manner compared to the traditional hybridization. Further, increase of interest to DNA based sensors can be expected in near future together with a commercial production of these devices and their extensive use. However, basic research is still necessary to