Molecular Biomarkers & Diagnosis

Does BRAF V600E Mutation Enable Vemurafenib to be a Universal Candidate for Treating a Plethora of Cancers?

Abstract

Ebtissam Alerraqi

Neurologically, BRAF V600E mutation was detected in cerebellar anaplastic pilocytic astrocytoma, ganglioglioma, desmoplastic infantile astrocytoma, indeterminate cell tumor and interdigitating dendritic cell sarcoma. Hematologically, BRAF V600E mutation was also detected in multiple myeloma and several leukemias (hairy cell, chronic lymphocytic, prolymphocytic and acute lymphoblastic leukaemia).