Neurological Disorders

Effect of Chronic Stress in the Onset of Parkinsons Disease: Possible Role of Microglial Cells in Neuroinflammation

Abstract

Shuei Sugama, Bruno Conti and Yoshihiko Kakinuma

For many years, several studies have been conducted to investigate the effect of stress on the onset of Parkinson’s disease (PD), which is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). de Pablos et al. reported that stressed animals were associated with a higher rate of death of dopaminergic neurons in the substantia nigra, and that this effect was dependent on glucocorticoids