Neurological Disorders

Effect of Vascular Endothelial Growth Factor (VEGF) Loaded on Gelatin Sponge on Transected Facial Nerve Regeneration

Abstract

Kong Jun, Xin Jin, Hu Jie, Lin Yi Hai and Jiang Shize

Objective: To evaluate the local effect of vascular endothelial growth factor (VEGF) loaded on gelatin sponge on transected facial nerve regeneration.

Methods: Twelve male white SD rats were divided into two groups randomly (n=6): VEGF group and PBS (phosphate buffer saline) group. In the VEGF group the left facial nerve was transected and the stump was connected by silicone conduit filled with gelatin sponge loaded with VEGF. In PBS group the defect was connected by silicone conduit filled with gelatin sponge loaded with PBS. Functional assessment and morphological evaluation were studied 8 weeks after operation.

Results: Functional study of facial nerve, Electrophysiological assessment and morphometric indices confirmed a faster recovery of regenerated axons in VEGF group than in PBS group (P<0.01).

Conclusion: Local administration of nerve conduit consisting of VEGF and gelatin sponge will improve functional recovery and morphometric indices of facial nerve.

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