Medical Microbiology & Diagnosis

Effectivity of Caspofungin on the Resistant Isolates of Candida albicans

Abstract

Nusrat Perween, Harris M Khan and Nazish Fatima

Objective: To compare the performance of Caspofungin with the conventional antifungal drugs on the Candida albicans isolates.
Materials and methods: Cases and Samples: The present study was carried out in the Department of Microbiology J. N. Medical College, AMU. Total of 6000 patients included in the study. Samples were collected according to their clinical presentation.
Materials and methods: Cases and Samples: The present study was carried out in the Department of Microbiology J. N. Medical College, AMU. Total of 6000 patients included in the study. Samples were collected according to their clinical presentation.
Evaluation and comparision of antifungal activity of Caspofungin: a. Disc diffusion, and b. Broth mico dilution method.
Results: The susceptibility testing of Caspofungin and other conventional antifungal agents by broth dilution method revealed very low MIC of Caspofungin (0.062-1 μg/ml) as compared to fluconazole (1-64 μg/ml). Thus, Caspofungin proved to be more potent than other antifungals in vitro.
Conclusion: We found Caspofungin to be more potent on the resistant isolates of Candida albicans in vitro.