Okolo Raphael Chinweike*, Ufelle SA, Achukwu PU, Ugwu AC and Ugwu BI
Aims and objectives: The study's goal is to evaluate the haematopoietic and inflammatory indicators of people living with HIV/AIDS in Enugu North Senatorial Zone, Enugu State, Nigeria. Specifically, the effect of HAART on total blood counts in HIV patients and the influence of HIV infection on the inflammatory makers of HIV infected patients.
Materials and methods: The study employed a cross-sectional, prospective, hospital based clinical research on all consenting consecutive patients scheduled for ART treatment irrespective of age between the period of March 2020 to August 2020 at the General Hospital Nsukka that meet the eligibility criteria.
Subjects and sample size determination: The sample size of 137 was determining using Cochran formula for determining sample size, after which 137 subjects were purposively selected.
Statistical analysis: were expressed where appropriate as mean ± standard deviation. T-test was used in testing hypotheses at 5% level of significance.
Results: The differences in complete blood counts for WBC, RBC, MCV, HB, Platelet and neutrophil as indicated in the mean values of pre and post HAART was administered on HIV patients revealed that HAART improved patients WBC, RBC, MCV, HB, platelet and neutrophil respectively. The improvement in patients WBC, RBC and MCV was statistically significant (P<0.05). However, the difference in patients MCHC after the administration of HAART was not statistically significant different from patients MCHC before the administration of HAART (P>0.05). Hence, the administration of HAART on HIV patients did not improve MCHC of patients.
Conclusion: The improvement in the complete blood counts in HIV patients was an indication that HAART was effective in suppressing the activities of HIV in patients. Inflammation, as indicated by greater CRP is related to the immunosuppressant of the system whereas lower hsCRP is a good indicator to be used to monitor early effect of viral suppression of the patients affected by HIV
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