Journal of Nanosciences: Current Research

In vitro Antibacterial and Anticancer Potential of CeO₂ Nanoparticles Prepared by Co-precipitation and Green Synthesis Method

Abstract

Parvathya S, Venkatramanb BR

Cerium oxide nanoparticles (CeO₂ NPs) were synthesized through chemical (co-precipitation method) (C-CeO₂ NPs) and green synthetic route (A. indica leaf extract) (G-CeO₂ NPs) and comparative studies were also carried out in the first time. From the XRD Pattern of C-CeO₂ and G-CeO₂ NPs revealed that both were in cubic phase. The morphological and elemental compositions were identified by FESEM, TEM and EDAX spectra. The optical characterizations were carried out using UV-Visible and Photoluminescence spectral analysis. Further the FT-IR and FT-Raman analysis were also confirmed to formation of CeO₂ nanoparticles. The oxidation states of the elements Ce (3d), C (1s) and O (1s) were confirmed by XPS studies. The green synthesized CeO2 NPs possessed a higher antibacterial activity than chemical CeO₂ NPs. The cytotoxic effect of C-CeO2 and G-CeO₂ NPs were analyzed in cultured (A549) human lung cancer cell line.