Medicinal Chemistry

Enantioselective Synthesis of β-amino acids: A Review

Abstract

Muhammad Ashfaq, Rukhsana Tabassum, Muhammad Mahboob Ahmad, Nagina Ali Hassan, Hiroyuki Oku and Gildardo Rivera

The synthesis of enantioselective β-amino acids is being reported in this review on account of their significant properties as proteinogenic, non-proteinogenic role such as neurotransmitter, biosynthesizer and nutritional supplementing materials etc. They are extensively used as chiral starting materials, auxiliariesand catalystsin organic synthesis. According to literature evidences, extensive research has been carried out to develop the methodologies for the synthesis of stereoselective β-amino acids. In this review, we describe recent advances in synthetic routes of enantioselective β-amino acids derivatives with chemical reactions during the last decades and to provide the most suitable route of their synthesis to compete the future challenges.