This review examines the potential of vinorelbine, a vinca alkaloid with established cytotoxic properties, to enhance the efficacy of radiotherapy in HepatoCellular Carcinoma (HCC). Radiotherapy plays a critical role in the management of HCC, especially in cases where surgical resection or liver transplantation is not feasible. However, the inherent radio resistance of HCC often limits treatment outcomes. Vinorelbine's ability to sensitize cancer cells to radiation through various mechanisms, including cell cycle modulation, DNA damage repair inhibition and apoptosis induction, is explored. The review synthesizes current literature to elucidate the molecular mechanisms underlying the synergistic effects of vinorelbine and radiotherapy in HCC treatment. Insights gained from this review may guide future research and clinical strategies aimed at optimizing combination therapies for improved outcomes in HCC patients.
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